Of Stances, Themes, and Anomalies in COVID-19 Mask-Wearing Tweets

COVID-19 is an opportunity to study public acceptance of a ‘‘new’’ healthcare intervention, universal masking, which unlike vaccination, is mostly alien to the Anglosphere public despite being practiced in ages past. Using a collection of over two million tweets, we studied the ways in which proponents and opponents of masking vied for influence as well as the themes driving the discourse. Pro-mask tweets encouraging others to mask up dominated Twitter early in the pandemic though its continued dominance has been eroded by anti-mask tweets criticizing others for their masking behavior. Engagement, represented by the counts of likes, retweets, and replies, and controversiality and disagreeableness, represented by ratios of the aforementioned counts, favored pro-mask tweets initially but with anti-mask tweets slowly gaining ground. Additional analysis raised the possibility of the platform owners suppressing certain parts of the mask-wearing discussion

Distinguishing between fake news and satire with transformers

Indiscriminate elimination of harmful fake news risks destroying satirical news, which can be benign or even beneficial, because both types of news share highly similar textual cues. In this work we applied a recent development in neural network architecture, transformers, to the task of separating satirical news from fake news. Transformers have hitherto not been applied to this specific problem. Our evaluation results on a publicly available and carefully curated dataset show that the performance from a classifier framework built around a DistilBERT architecture performed better than existing machine-learning approaches. Additional improvement over baseline DistilBERT was achieved through the use of non-standard tokenization schemes as well as varying the pre-training and text pre-processing strategies. The improvement over existing approaches stands at 0.0429 (5.2%) in F1 and 0.0522 (6.4%) in accuracy. Further evaluation on two additional datasets shows our framework\u27s ability to generalize across datasets without diminished performance

The Role of Reinfection and Partner Notification in the Efficacy of Chlamydia Screening Programs

Repeated Chlamydia trachomatis infections after treatment are common. One reason is reinfection from untreated partners in ongoing sexual partnerships. Mathematical models that are used to predict the impact of screening on reducing chlamydia prevalence often do not incorporate reinfection and might overestimate the expected impact. We describe a pair compartmental model that explicitly incorporates sexual partnership duration and reinfection. The pair model predicts a weaker impact of screening when compared directly with a model that does not accommodate partnerships. Effective management of sex partners to prevent reinfection might need to be strengthened in chlamydia control program

Ginseng and Ginkgo Biloba effects on cognition as modulated by cardiovascular reactivity: A randomised trial

Background There is some evidence to suggest that ginseng and Ginkgo biloba can improve cognitive performance, however, very little is known about the mechanisms associated with such improvement. Here, we tested whether cardiovascular reactivity to a task is associated with cognitive improvement. Methodology/Principal findings Using a double-blind, placebo controlled, crossover design, participants (N = 24) received two doses of Panax Ginseng (500, 1000 mg) or Ginkgo Biloba (120, 240 mg) (N = 24), and underwent a series of cognitive tests while systolic, diastolic, and heart rate readings were taken. Ginkgo Biloba improved aspects of executive functioning (Stroop and Berg tasks) in females but not in males. Ginseng had no effect on cognition. Ginkgo biloba in females reversed the initial (i.e. placebo) increase in cardiovascular reactivity (systolic and diastolic readings increased compared to baseline) to cognitive tasks. This effect (reversal) was most notable after those tasks (Stroop and Iowa) that elicited the greatest cardiovascular reactivity during placebo. In males, although ginkgo also decreased cardiovascular readings, it did so from an initial (placebo) blunted response (i.e. decrease or no change from baseline) to cognitive tasks. Ginseng, on the contrary, increased cardiovascular readings compared to placebo. Conclusions/Significance These results suggest that cardiovascular reactivity may be a mechanism by which ginkgo but not ginseng, in females is associated with certain forms of cognitive improvement

Climate policy for a net-zero future: ten recommendations for Direct Air Capture

Direct Air Capture with Carbon Storage (DACCS) technologies represent one of the most significant potential tools for tackling climate change by making net-zero and net-negative emissions achievable, as deemed necessary in reports from the Intergovernmental Panel on Climate Change and the European Green Deal. We draw from a novel and original dataset of expert interviews (N = 125) to distil ten recommendations for future DACCS policy. After providing a literature review on DACCS and explaining our methods of data collection, we present these recommendations as follows: (a) follow governance principles that ensure 'negative' emissions; (b) prioritize long-term carbon storage; (c) appreciate and incentivize scale; (d) co-develop with capture, transport, and storage; (e) phase in a carbon price; (f) couple with renewables; (g) harness hub deployment; (h) maintain separate targets; (i) embrace certification and compliance; and (j) recognize social acceptance. All ten recommendations are important, and all speak to the urgency and necessity of better managing and shaping the potentially impending DACCS transition

A synonymous codon variant in two patients with autosomal recessive bestrophinopathy alters in vitro splicing of BEST1

Purpose: Autosomal recessive bestrophinopathy (ARB) is a newly defined retinal dystrophy caused by biallelic mutations in bestrophin-1 (BEST1) and is hypothesized to represent the null bestrophin-1 phenotype in humans. The aim was to determine whether a synonymous BEST1 variant, c.102C>T, identified in two unrelated ARB patients, alters pre-mRNA splicing of the gene. Additionally a detailed phenotypic characterization of this distinctive condition is presented for both patients.Methods: BEST1 was analyzed by direct sequencing. Patients underwent standard ophthalmic assessment. In silico and in vitro analysis using a minigene system was performed to assess whether a synonymous variant identified, c.102C>T p.Gly34Gly, alters pre-mRNA splicing of BEST1.Results: Both ARB patients harbored either proven (patient 1; c.102C>T p.Gly34Gly and c.572T>C p.Leu191Pro) or presumed (patient 2; c.102C>T p.Gly34Gly and c.1470_1471delCA, p.His490GlnfsX24) biallelic mutations in BEST1 and were found to have phenotypes consistent with ARB. In vitro analysis of the synonymous variant, c.102C>T p.Gly34Gly, demonstrated it to introduce a cryptic splice donor site 52 nucleotides upstream of the actual splice donor site.Conclusions: The novel BEST1 variant identified, c.102C>T p.Gly34Gly, alters pre-mRNA splicing in vitro and is potentially pathogenic. In vivo this splicing variant is predicted to lead to the production of an mRNA transcript with a premature termination codon (p.Glu35TrpfsX11) that is predicted to be degraded by NMD

Exogenous NG-hydroxy-l-arginine causes nitrite production in vascular smooth muscle cells in the absence of nitric oxide synthase activity

AbstractNitric oxide (NO) production from exogenous NG-hydroxy-l-arginine (OH-l-Arg) was investigated in rat aortic smooth muscle cells in culture by measuring nitrite accumulation in the culture medium. As well, the interaction between OH-l-Arg and l-arginine uptake via the y+ cationic amino acid transporter was studied. In cells without NO-synthase activity, OH-l-Arg (1–1000 μM) induced a dose-dependent nitrite production with a half-maximal effective concentration (EC50) of 18.0 ± 1.5 μM (n = 4–7). This nitrite accumulation was not inhibited by the NO-synthase inhibitor NG-nitro-l-arginine methyl ester, l-NAME (300 μM). In contrast, it was abolished by miconazole (100 μM), an inhibitor of cytochrome P450. Incubation of vascular smooth muscle cells with LPS (10 μgml) induced an l-name inhibited nitrite accumulation, but did not enhance the OH-l-Arg induced nitrite production. OH-l-Arg and other cationic amino acids, L-lysine and l-ornithine, competitively inhibited [3H]-l-arginine uptake m rat aortic smooth muscle cells, with inhibition constants of 195 ± 23 μM(n = 12), 260 ± 40 μM(n= 5) and 330 ± 10 μM(n = 5), respectively. These results show that OH-l-Arg is recognized by the cationic l-amino acid carrier present in vascular smooth muscle cells and can be oxidized to NO and nitrite in these cells in the absence of NO-synthase, probably by cytochrome P450 or by a reaction involving a cytochrome P450 byproduct

Extension of the sum rule for the transition rates between multiplets to the multiphoton case

The sum rule for the transition rates between the components of two multiplets, known for the one-photon transitions, is extended to the multiphoton transitions in hydrogen and hydrogen-like ions. As an example the transitions 3p-2p, 4p-3p and 4d-3d are considered. The numerical results are compared with previous calculations.Comment: 10 pages, 4 table

Oxidised cosmic acceleration

We give detailed proofs of several new no-go theorems for constructing flat four-dimensional accelerating universes from warped dimensional reduction. These new theorems improve upon previous ones by weakening the energy conditions, by including time-dependent compactifications, and by treating accelerated expansion that is not precisely de Sitter. We show that de Sitter expansion violates the higher-dimensional null energy condition (NEC) if the compactification manifold M is one-dimensional, if its intrinsic Ricci scalar R vanishes everywhere, or if R and the warp function satisfy a simple limit condition. If expansion is not de Sitter, we establish threshold equation-of-state parameters w below which accelerated expansion must be transient. Below the threshold w there are bounds on the number of e-foldings of expansion. If M is one-dimensional or R everywhere vanishing, exceeding the bound implies the NEC is violated. If R does not vanish everywhere on M, exceeding the bound implies the strong energy condition (SEC) is violated. Observationally, the w thresholds indicate that experiments with finite resolution in w can cleanly discriminate between different models which satisfy or violate the relevant energy conditions.Comment: v2: corrections, references adde

Svestka's Research: Then and Now

Zdenek Svestka's research work influenced many fields of solar physics, especially in the area of flare research. In this article I take five of the areas that particularly interested him and assess them in a "then and now" style. His insights in each case were quite sound, although of course in the modern era we have learned things that he could not readily have envisioned. His own views about his research life have been published recently in this journal, to which he contributed so much, and his memoir contains much additional scientific and personal information (Svestka, 2010).Comment: Invited review for "Solar and Stellar Flares," a conference in honour of Prof. Zden\v{e}k \v{S}vestka, Prague, June 23-27, 2014. This is a contribution to a Topical Issue in Solar Physics, based on the presentations at this meeting (Editors Lyndsay Fletcher and Petr Heinzel